Honestly unless you have a fab shop, a single shock on a regular (double sided versus single sided) swingarm wouldnt save much weight. Also taking a stock Dyna frame and doing this would be a headache. Now if you do and have a CNC machine and a big chunk of billet, you could save some weight and with said machine shop, you could build your own frame.
The thing with sporties (and Buell) is its a one piece design (motor and trans in same cases), which means the options for customizing is easier.
With a rubber mount motor/trans/transplate set up, you would need the rear suspension to have the rubber pieces at the main rear swing arm bolt to make it ride like it was designed.
Also the Twinkie has more limitations with the frame size and so on. Forgive my ignorance on the plethora of aftermarket availability for Twin cams, but I havent worked them much. My custom bike experience is limited up to Evo style motors, yet included rubber mounts. (which if is built wrong or not lined up right will give you're leather cheerio a workout death wobblin tank slapper, pray the ass nipple you leave on the seat is the ONLY damage the thing gets)
This is an endevour for a fabricator who knows his shit with twin cams, rubber mounts and frame design.
Not saying your not, but you left alot up the imagination.
This is not a good idea for your average "garage doctor." And if you're doing it just to do it and not win the next biker build off (if they ever come back), the amount of money time and effort really wouldnt be worth it, to me.
Just my $0.02....